The Clinical Role of Nitric Oxide and L-arginine in Asthma
نویسنده
چکیده
NO is an important biological marker in the activity of the inflammatory process and endothelial dysfunction in bronchopulmonary diseases. Endothelial dysfunction appears as a primary element for vessel wall lesion that causes formation of the cardiovascular effects in asthma. Cardiovascular effects are considered as system displays of various diseases, among which endothelial dysfunction appears as the primary element of a vessel wall lesion. Studying NO metabolites and L-arginine content plays an important role for required correction in the respiratory system endothelium.
منابع مشابه
Effect of Nitric Oxide on Basolateral Amygdala on Persistence of Anxiety and Depression in Stressed Male Rats
Introduction: The current study aimed at investigating the role of Nitric Oxide (NO) in the maintenance of anxiety and depression induced by stress in male Wistar rats using intra-Basolateral Amygdala (BLA) injection of NO precursor, L-arginine, Nitric Oxide Synthase (NOS) inhibitor, and L-NAME. Methods: Two 23-gauge stainless steel cannulas were placed in the BLA, stereotaxically. Seven days...
متن کاملEffect of Neutrophils on Nitric Oxide Production from Stimulated Macrophages
Background: During the initial phase of an infection, there is an upregulation of inducible nitric oxide synthase in the macrophages for the production of nitric oxide. This is followed by the recruitment of polymorphonuclear leukocytes (neutrophils) which release arginase. Arginase competes with inducible nitric oxide synthase for a common substrate L-arginine. Objective: To investigate whethe...
متن کاملEvaluation of nitric oxide involvement in effect of lead on dependency to morphine in mice
In the present study, interactions between lead exposure with nitric oxide precursor (L-arginine) or nitric oxide synthase (NOS) inhibitor (L-NAME) on naloxone-induced jumping and diarrhea in morphine-dependent mice were examined. Chronic lead acetate (0.05%) exposure altered naloxone-induced jumping and diarrhea in mice. Jumping was decreased after 7 days and was unchanged 14 and 28 days after...
متن کاملNitric Oxide is Protective Against Mercury Induced Depression
A B S T R A C T Introduction: Mercury is the second most metal pollutant in the world and has the potential to induce many pathologic conditions, especially in nervous system, such as depression. Here we tried to find out if nitric oxide has any possible role in the pathophysiology of depression induced by this metal. Although the role of nitric oxide has been shown in mood control, here we use...
متن کاملThe role of nitric oxide in conditioned place preference induced by morphine in male mice
The involvement of nitric oxide (NO) in the reinforcing properties of opioids was studied by examining the effect of a NO precursor (L-arginine) and NO synthase inhibitor (L-nitro-amino-methyl-ester, L-NAME) on the conditioned place preference (CPP) induced by morphine. The experiment was performed on male albino Swiss- White mice (25 ± 5 g). L-arginine in doses of 100, 200 and 500 mg/kg (i.p...
متن کاملNitric oxide within the rat hippocampal CA1 area may play a role in morphine tolerance
Hippocampus as part of the limbic system plays an important role in abused drugs-induced memory. The role of glutamate receptor within the hippocampal CA1 area in morphine-induced memory has also been postulated. Previous studies indicated that glutamate receptors exert their effects in part through the release of nitric oxide (NO). In the present study, the effects of intra-CA1 area injections...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015